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DTSTART:20200329T030000
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DTSTART:20191027T020000
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BEGIN:VEVENT
DTSTAMP:20260406T000349Z
UID:5ddfd0429f4b2689738555@ist.ac.at
DTSTART:20191218T110000
DTEND:20191218T123000
DESCRIPTION:Speaker: Anusha Sathyanarayanan\nhosted by Carl-Philipp Heisenb
 erg\nAbstract: The mouse blastocyst consists of three lineages: epiblast t
 hat will form the foetus and two extraembryonic lineages  trophectoderm (T
 E) and primitive endoderm (PE) that support the development of the embryo.
  Here\, we established novel extraembryonic cell lines (TE-like cells) tha
 t show extended developmental potential\, capturing features of both TE an
 d PE lineages. These cells were derived directly from blastocyst stage emb
 ryos or established in vitro via chemical reprogramming of XEN state cells
 . We deciphered the mechanism of conversion\, as well as the developmental
  potential and the self-organization properties of the TE-like cells. We f
 ound that these cells are specified following the same morphogenetic and s
 ignalling cues that determine the TE fate during pre-implantation embryoge
 nesis. Moreover\, upon aggregation with embryonic stem cells\, they form b
 lastocyst-like structures that initiate implantation when transferred into
  a recipient mother. Thus\, the self-organization properties of the TE-lik
 e cells can provide an in vitro platform for dissecting the processes of e
 arly lineage self-assembly\, mechanisms of cell-cell recognition and sorti
 ng\, blastocoel cavity formation and cell fate transitions in the early ma
 mmalian embryo.
LOCATION:Meeting room 3rd floor / Central Bldg. (I01.3OG.Meeting Room)\, IS
 TA
ORGANIZER:lalesch@ist.ac.at
SUMMARY:Anusha Sathyanarayanan: Establishment and self-organisation of trop
 hectoderm-like cells into artificial embryos
URL:https://talks-calendar.ista.ac.at/events/2429
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