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DTSTART:20200329T030000
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DTSTART:20191027T020000
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DTSTAMP:20260406T023958Z
UID:5db7f2d1b9fbb133886583@ist.ac.at
DTSTART:20191213T110000
DTEND:20191213T120000
DESCRIPTION:Speaker: Anna Akhmanova\nhosted by Michael Sixt\nAbstract: Tigh
 t control of microtubule dynamics is essential for many cellular processes
 \, including cell division\, migration and morphogenesis. Using in vitro r
 econstitution experiments\, we explored the detailed mechanisms of such re
 gulation by proteins that interact with microtubule plus ends. Furthermore
 \, we used assays with fluorescent analogues of microtubule-stabilizing an
 d destabilizing agents to directly visualize their effects on microtubule 
 polymerization. We found that a single molecule of a microtubule-depolymer
 izing drug bound to the microtubule tip was sufficient to trigger a catast
 rophe\, whereas microtubule rescue and stabilization required local accumu
 lation of multiple drug molecules. Our results illustrate the diversity an
 d complexity of mechanisms controlling microtubule growth and organization
 .
LOCATION:Mondi Seminar Room 1\, Central Building\, ISTA
ORGANIZER:astawick@ist.ac.at
SUMMARY:Anna Akhmanova: Control of microtubule dynamics: seeing proteins an
 d drugs in action
URL:https://talks-calendar.ista.ac.at/events/2405
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