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DTSTAMP:20260407T122639Z
UID:5dc19dab03b84251152612@ist.ac.at
DTSTART:20191120T150000
DTEND:20191120T160000
DESCRIPTION:Speaker: Guillaume Attuel\nhosted by Fabrizio Lombardi\nAbstrac
 t: Cardiac fibrillation is a rapid arrhythmia that affects the atria and v
 entricles\, still posing major challenges to public health management. Atr
 ial fibrillation is the predominant cause of embolic stroke while ventricu
 lar fibrillation leads to sudden cardiac death. The consensus pictures car
 diac fibrillation as being triggered by a source of abnormal activity and 
 maintained by multiple reentries of the electric pulses. The myocardium is
  seen basically as a syncytium of connected cells. Therefore\, a relativel
 y safe combined therapy of anti-arrhythmic drug delivery with catheter abl
 ation has been implemented aiming at knocking off those two factors. After
  two decades of this strategy\, it has been shown to be suboptimal with no
  foreseeable cure.Recently (10.3389/fphys.2017.01139 and 10.3389/fphys.201
 9.00480)\, we have provided evidence and modeling which clash with the acc
 epted wisdom. Incompatibility is uncovered in recordings of the electrical
  activity of fibrillating human hearts\, because multifractal scaling is f
 ound\, with which the model shows excellent quantitative agreement.The mod
 el focuses on a kinetic instability of junctional channels generating a ch
 aotic modulation of conductance. The important multifractal parameter is r
 elated to the variance of the strong capacitive electric field\, building 
 up across cell junctions.If this is true\, during fibrillation\, electric 
 recordings have been mistakenly taken for cardiac action potentials instea
 d of a mixture with capacitive currents\, invalidating in practice a host 
 of methods for signal visualization and interpretation.A puzzle\, common t
 o cardiac recordings and time series in the model\, which comes as a surpr
 ise\, is the absence of log-correlations. Beside being mathematically chal
 lenging to understand\, this trait imposes strict constraints about the po
 ssible underlying mechanism.In this respect\, the model also puts under sc
 rutiny unknown mechanisms of the biology of connexins\, the ubiquitous pro
 teins which make up gap junction channels.
LOCATION:Mondi Seminar Room 3\, Central Building\, ISTA
ORGANIZER:abonvent@ist.ac.at
SUMMARY:Guillaume Attuel: Cardiac fibrillation : an interdisciplinary puzzl
 e
URL:https://talks-calendar.ista.ac.at/events/2402
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