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TZID:Europe/Vienna
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DTSTART:20190331T030000
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DTSTART:20191027T020000
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BEGIN:VEVENT
DTSTAMP:20260406T041136Z
UID:5dad536e91795926910217@ist.ac.at
DTSTART:20191023T130000
DTEND:20191023T140000
DESCRIPTION:Speaker: Timo Betz\nhosted by Michael Sixt\nAbstract: Living bi
 ological systems are continuously reorganizing their structure to perform 
 their function. The mechanical activity plays here an important role\, as 
 the constant generation of forces drives fluctuations as well as controlle
 d motion of intracellular particles\, membranes and cells. From a biophysi
 cal point of view\, this active motion drives the system far away from the
 rmodynamic equilibrium\, which can be measured as a violation of equilibri
 um quantities such as the fluctuation dissipation theorem. Quantifying the
  out-of-equilibrium components provides the possibility to model the activ
 e molecular processes. We measure the energy and the forces actively appli
 ed on membranes as well as cellular granules and model these with an activ
 e Langevin approach. This allows extracting molecular parameters of the fo
 rce generating processes. Besides these intracellular forces\, we also qua
 ntify migration in the single cell and tissue level\, by investigating mig
 ration patterns and traction forces in 3D of in vitro cancer spheroids emb
 edded in collagen I matrices\, as well as the initial collective cell migr
 ation in zebrafish development\, called epiboly.
LOCATION:Mondi Seminar Room 1\, Central Building\, ISTA
ORGANIZER:astawick@ist.ac.at
SUMMARY:Timo Betz: Active cell mechanics: From fluctuations of red blood ce
 lls to cell migration in development and cancer.
URL:https://talks-calendar.ista.ac.at/events/2369
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