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DTSTART:20190331T030000
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DTSTART:20191027T020000
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DTSTAMP:20260405T162031Z
UID:5da445c078377365538629@ist.ac.at
DTSTART:20191023T113000
DTEND:20191023T123000
DESCRIPTION:Speaker: Benjamin Zoller\nhosted by Gasper Tkacik\nAbstract: Ho
 w transcriptional bursting relates to gene regulation is a central questio
 n that has persisted for more than a decade. Here\, we measure nascent tra
 nscriptional activity in early Drosophila embryos and characterize the var
 iability in absolute activity levels across expression boundaries. We demo
 nstrate that boundary formation follows a common transcription principle: 
 a single control parameter determines the distribution of transcriptional 
 activity\, regardless of gene identity\, boundary position\, or enhancer-p
 romoter architecture. We infer the underlying bursting kinetics and identi
 fy the key regulatory parameter as the fraction of time a gene is in a tra
 nscriptionally active state. Unexpectedly\, both the rate of polymerase in
 itiation and the switching rates are tightly constrained across all expres
 sion levels\, predicting synchronous patterning outcomes at all positions 
 in the embryo. These results point to a shared simplicity underlying the a
 pparently complex transcriptional processes of early embryonic patterning 
 and indicate a path to general rules in transcriptional regulation.
LOCATION:Mondi Seminar Room 1\, Central Building\, ISTA
ORGANIZER:abonvent@ist.ac.at
SUMMARY:Benjamin Zoller: Transcriptional regulation of developmental genes
URL:https://talks-calendar.ista.ac.at/events/2367
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