BEGIN:VCALENDAR VERSION:2.0 PRODID:icalendar-ruby CALSCALE:GREGORIAN METHOD:PUBLISH BEGIN:VTIMEZONE TZID:Europe/Vienna BEGIN:DAYLIGHT DTSTART:20190331T030000 TZOFFSETFROM:+0100 TZOFFSETTO:+0200 RRULE:FREQ=YEARLY;BYDAY=-1SU;BYMONTH=3 TZNAME:CEST END:DAYLIGHT BEGIN:STANDARD DTSTART:20191027T020000 TZOFFSETFROM:+0200 TZOFFSETTO:+0100 RRULE:FREQ=YEARLY;BYDAY=-1SU;BYMONTH=10 TZNAME:CET END:STANDARD END:VTIMEZONE BEGIN:VEVENT DTSTAMP:20260404T064851Z UID:5d9f11771bbae930438944@ist.ac.at DTSTART:20191016T143000 DTEND:20191016T153000 DESCRIPTION:Speaker: Hansruedi Mathys\nhosted by Sandra Siegert\nAbstract: Alzheimers disease is a pervasive neurodegenerative disorder\, the molecul ar complexity of which remains poorly understood. Here\, we analysed 80\,6 60 single-nucleus transcriptomes from the prefrontal cortex of 48 individu als with varying degrees of Alzheimers disease pathology. Across six major brain cell types\, we identified transcriptionally distinct subpopulation s\, including those associated with pathology and characterized by regulat ors of myelination\, inflammation\, and neuron survival. The strongest dis ease-associated changes appeared early in pathological progression and wer e highly cell-type specific\, whereas genes upregulated at late stages wer e common across cell types and primarily involved in the global stress res ponse. Notably\, we found that female cells were overrepresented in diseas e-associated subpopulations\, and that transcriptional responses were subs tantially different between sexes in several cell types\, including oligod endrocytes. Overall\, myelination-related processes were recurrently pertu rbed in multiple cell types\, suggesting that myelination has a key role i n Alzheimers disease pathophysiology. Our single-cell transcriptomic resou rce provides a blueprint for interrogating the molecular and cellular basi s of Alzheimers disease. LOCATION:Mondi Seminar Room 2\, Central Building\, ISTA ORGANIZER:jdeanton@ist.ac.at SUMMARY:Hansruedi Mathys: Single-cell transcriptomic analysis of Alzheimer ’s disease reveals cell type- and sex-specific pathophysiology URL:https://talks-calendar.ista.ac.at/events/2355 END:VEVENT END:VCALENDAR