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DTSTART:20190331T030000
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DTSTART:20191027T020000
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BEGIN:VEVENT
DTSTAMP:20260406T000501Z
UID:5da42a06950a3300101520@ist.ac.at
DTSTART:20191025T100000
DTEND:20191025T110000
DESCRIPTION:Speaker: Md. Jahirul Islam\nhosted by Ryuichi Shigemoto\nAbstra
 ct: Motor proteins including kinesin and myosin are very important bio-mol
 ecular motors which fulfil crucial cellular functions (e.g. intracellular 
 transport\, muscle contraction) in living system. Over the past decades\, 
 significant attempts have been made not only to understand the motile func
 tion of motor proteins for biomedical application\, but also to develop pr
 ecise controllable nano-devices using bio-molecular motors. In Tamaoki lab
  two approaches\, namely controllable high-energy molecules and inhibitors
  for the motor proteins have been used to optically control the motor prot
 ein function in reversible manner with high spatio-temporal control.1 Amon
 g other things\, I will describe the noble non-nucleoside azobenzene-triph
 osphates (AzoTP and its analogues\, Fig 1) as photoswitchable energy molec
 ules for kinesin2 as well as myosin3 to optically regulate the motility of
  their associated cytoskeletal filaments in an in vitro motility assay. Th
 e usability of the photoswitchable energy molecules toward myosin-actin mo
 tile system at the macroscopic level\, shortening of a glycerinated muscle
  fiber will be demonstrated. Furthermore\, I will describe the discovery o
 f the myosin selective azobenzene-triphosphate which enables the specific 
 photocontrol of myosin with a reversible mode in a composite motility assa
 y composed of both kinesin and myosin bio-molecular motors.4 Besides that\
 , I will discuss the photo-responsive azobenzene-triphosphate inhibitor (A
 zoMP-PCP/AzoMP-PNP) for kinesin and myosin\, where the inhibitors were der
 ived from replacing the -O- bridge in the β-γ phosphate bond of the azob
 enzene-triphosphate with -CH2- and -NH- bridge.References[1] A. S. Amrutha
 \, K. R. S. Kumar and N. Tamaoki\, ChemPhotoChem\, 2019\, 3\, 337-346[2] N
 . Perur\, M. Yahara\, T. Kamei and N. Tamaoki\, Chem. Commun.\, 2013\, 49\
 , 9935-9937[3] H. M. Menezes\, M. J. Islam\, M. Takahashi and N. Tamaoki\,
  Org. Biomol. Chem.\, 2017\, 15\, 8894-8903[4] M. J. Islam\, K. Matsuo\, H
 . M. Menezes\, M. Takahashi\, H. Nakagawa\, A. Kakugo\, K. Sada and N. Tam
 aoki\, Org. Biomol. Chem.\, 2019\, 17\, 53-65
LOCATION:Mondi Seminar Room 3\, Central Building\, ISTA
ORGANIZER:lmarr@ist.ac.at
SUMMARY:Md. Jahirul Islam: Reversible Photo-Regulation of Motor Proteins Us
 ing Photo-Responsive Triphosphate Molecules
URL:https://talks-calendar.ista.ac.at/events/2354
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