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DTSTART:20190331T030000
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DTSTAMP:20260405T161906Z
UID:5d94ae6c4fa36087888811@ist.ac.at
DTSTART:20191018T150000
DTEND:20191018T160000
DESCRIPTION:Speaker: Yiteng Dang\nhosted by Gasper Tkacik\nAbstract: How a 
 system of genetically identical biological cells organizes into spatially 
 heterogeneous tissues is a central question in biology. Even when the mole
 cular and genetic underpinnings of cell-cell interactions are known\, how 
 these lead to pattern formation at the population level is often incomplet
 ely understood. We studied the gene expression dynamics of cells that secr
 ete and sense signaling molecules by developing a multiscale model and an 
 open-source software for simulating mesoscopic numbers of cells (hundreds 
 to thousands). We observed that the cells self-organized into diverse spat
 ial patterns without external morphogen gradients. To understand our obser
 vations\, we constructed a coarse-grained\, population-level description o
 f our system. This revealed a conceptual picture of our multicellular syst
 em as a particle rolling down a pseudo-energy landscape. An approximate eq
 uation for the dynamics on this landscape explains how and why the system 
 becomes increasingly spatially ordered over time. Next\, we studied how dy
 namic patterns such as collective oscillations and travelling waves formed
  when cells communicate with multiple signaling molecules. Through a compu
 tational screen and a theoretical framework I developed\, we found a commo
 n structure to the gene networks characterizing the interactions between t
 wo signaling molecules  that enable these dynamic patterns to form. Furthe
 rmore\, they emerge through a three-stage order-fluctuate-settle process\,
  where the final pattern forms after a long period of fluctuations and tra
 nsient patterns. Our work provides a blueprint for identifying gene regula
 tory links that enable dynamic patterns and for building synthetic tissues
 .
LOCATION:Mondi Seminar Room 2\, Central Building\, ISTA
ORGANIZER:dboocock@ist.ac.at
SUMMARY:Yiteng Dang: Collective dynamics in systems of communicating secret
 e-and-sense cells
URL:https://talks-calendar.ista.ac.at/events/2344
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