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DTSTART:20170326T030000
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DTSTAMP:20260428T211929Z
UID:57209db7e4d99247707989@ist.ac.at
DTSTART:20161121T160000
DTEND:20161121T171500
DESCRIPTION:Speaker: Alfonso Martinez Arias\nAbstract: Embryonic Stem (ES) 
 cells are clonal derivatives from the blastocysts of mammalian embryos whi
 ch have the potential to give rise to all lineages of the embryo and the a
 bility to self-renew this ability. Mouse ES cells have proven an excellent
  system in which to study developmental events\, in particular the mechani
 sms of cell fate decisions. However\, while it is easy to coax them into e
 lements of different tissues in culture\, they do not organize themselves 
 as they do in embryos. Non adherent culture leads them to form aggregates 
 in which some cell types appear in clusters but there is no overall organi
 zation.\nRecently we have developed a non-adherent culture system in which
  small aggregates of mouse ES cells undergo symmetry breaking\, polarized 
 gene expression and growth and gastrulation like movements in vitro. Using
  a variety of reporter ES cell lines and comparison with the embryo we obs
 erve organization of Wnt\, Nodal and FGF signaling that mirrors events in 
 the embryo and have shown that they can develop in culture until an equiva
 lent of embryonic day 9 (E9). We observe that these embryonic organoids de
 velop anteroposterior\, dorsoventral as well as bilateral asymmetries. Ana
 lysis of pattern formation in these aggregates suggests that they do not d
 evelop through standard self-organization but that there is a strong genet
 ic components to what otherwise would be simple thermodynamically driven p
 rocess. These issues will be discussed in course of the talk.\nAn importan
 t value of this organoid system is the ability to generate spatially organ
 ized niches and we have used this system to study the emergence and dynami
 cs of a stem/progenitor population that gives rise to the spinal cord and 
 the paraxial mesoderm.
LOCATION:Raiffeisen Lecture Hall\, Central Building\, ISTA
ORGANIZER:aeller@ist.ac.at
SUMMARY:Alfonso Martinez Arias: The Institute Colloquium: Genetically super
 vised axial (self) organization in aggrega
URL:https://talks-calendar.ista.ac.at/events/216
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