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DTSTART:20190331T030000
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DTSTART:20191027T020000
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DTSTAMP:20260404T015840Z
UID:5d653f210b95e922512903@ist.ac.at
DTSTART:20190910T110000
DTEND:20190910T121500
DESCRIPTION:Speaker: Jacques Prost\nhosted by Edouard Hannezo\nAbstract: Af
 ter introducing the main features characterizing an elementary contractile
  unit in cells\, I will recall theoretical results concerning motor collec
 tions obtained over the years. In particular I will show how a symmetry br
 eaking transition\, emergent feature of a large number of molecular motors
 \, underpins a number of biological functions based on muscle oscillations
 . I will then show how a simple modification of the theoretical framework 
 allows to understand all experimental observations on elementary contracti
 le unit including force build-up followed by a relaxation and the existenc
 e of half integer steps in the contraction/relaxation curve\, which is a r
 esurgence of a nanoscopic scale in a mesoscopic system. I will then change
  gear completely\, and propose a description of polar tissues in a planar 
 and spherical geometry. In particular\, I will show that\, in the planar g
 eometry\, flow and electric fields can induce either proliferation or deat
 h of thick epithelia\, and that in a spherical geometry a lumen can be for
 med. Ref:Myosin filaments reversibly generate large forces in cellsJ Lohne
 r\, JF Rupprecht\, et al Nature Physics 2019 Field induced cell proliferat
 ion and death in a thick epitheliumN Sarkar\, J Prost\, F Jlicher New J. P
 hys 2019Fluid pumping and active flexoelectricity can promote lumen nuclea
 tion in cell assembliesC Duclut\, N Sarkar\, J Prost\, F Julicher\, PNAS\,
  2019
LOCATION:Mondi Seminar Room 2\, Central Building\, ISTA
ORGANIZER:channezo@ist.ac.at
SUMMARY:Jacques Prost: A few bets from molecular scales to tissue scales: f
 rom emergence and resurgence in elementary contractile unit to electric fi
 eld induced proliferation and lumen formation
URL:https://talks-calendar.ista.ac.at/events/2081
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