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DTSTART:20200329T030000
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DTSTART:20191027T020000
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DTSTAMP:20260403T220521Z
UID:5d3e77f2e8e1a404987438@ist.ac.at
DTSTART:20191212T110000
DTEND:20191212T121500
DESCRIPTION:Speaker: Caroline Hill\nhosted by Anna Kicheva\nAbstract: Carol
 ine Hills lab at the Francis Crick Institute in London is focused on study
 ing cell signalling. In particular\, she is interested in signalling by th
 e TGF-ß family of growth and differentiation factors. Tight regulation o
 f these signalling pathways is crucial for embryonic development in all or
 ganisms from worms and flies to humans\, and deregulation of these pathway
 s is a major cause of tumour growth and spread in cancer. Her lab is focus
 ed on understanding how these pathways are regulated and function in embry
 onic development and she uses zebrafish embryos as a system to study this.
  She also wants to understand how this signalling is deregulated in cancer
 \, with the ultimate aim of developing new therapeutics.Her talk will focu
 s on new work in the lab studying the mechanism whereby these signalling p
 athways activate transcription and her recent discovery of the mechanism w
 hereby the earliest domain of signalling by one of these family members (N
 odal) is established and shaped during early zebrafish development. This w
 ork has led her to an understanding of how Nodal signalling is involved in
  determining the choice between mesodermal and endodermal cell fates durin
 g early embryogenesis.
LOCATION:Mondi Seminar Room 2\, Central Building\, ISTA
ORGANIZER:srus@ist.ac.at
SUMMARY:Caroline Hill: TGF-ß superfamily signalling - an exploration in sp
 ace and time
URL:https://talks-calendar.ista.ac.at/events/2061
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