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DTSTART:20190331T030000
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DTSTAMP:20260405T215822Z
UID:5d5127f17cf28987670246@ist.ac.at
DTSTART:20190819T110000
DTEND:20190819T121500
DESCRIPTION:Speaker: Celine Dinet\nhosted by Carl-Philipp Heisenberg\nAbstr
 act: Cell adhesion is a crucial process that take place through the intera
 ction between a ligand and its receptor at the cell interface. The experim
 ental studies of this interface are challenging due to the lack of control
  of its chemical and physical properties. For this\, I use biomimetic appr
 oaches (artificial substrates or model membranes) to quantitatively contro
 l the biochemical and physical properties underlying the adhesion process.
 In the first part of my talk\, I will focus on the mechanosensitivity of T
 -cells\, a process at the heart of immune recognition. It takes place thro
 ugh bonds formed by their special receptor called the T-cell receptor or T
 CR. While the mechanobiology of TCR is well known\, its link to cell scale
  response is poorly understood. By following the spreading response of T-c
 ell on substrate of different rigidity\, we aim to study T -cell adhesion 
 and\, to which degree substrate rigidity has an influence. We show that T-
 cell response may be either monotonous or biphasic.For the second part\, I
  will present results on the remodelling of the adhesion contact as cells 
 expel water. This is important in the context of formation of lumen in emb
 ryos. We use a biomimetic model system of cell-to-cell adhesion comprised 
 of giant unilamellar vesicles (GUVs) adhering to a supported lipid bilayer
  or to other GUVs via specific biotin-neutravidin or cadherins bonds. Upon
  osmotically induced vesicle shrinking\, we observe the deformation of the
  membrane and the formation of water-filled pockets\, also seen in cells. 
 We show that the adhesion links are sheared away from the sites of pockets
  formation than recover with time. The size\, distribution and recovery dy
 namics depends on the magnitude of the osmotic shock and the adhesion stre
 ngth and density.
LOCATION:Meeting room 1st floor / Central Bldg. (I01.1OG - Zentralgebäude)
 \, ISTA
ORGANIZER:lalesch@ist.ac.at
SUMMARY:Celine Dinet: Cell adhesion in immunity and development
URL:https://talks-calendar.ista.ac.at/events/2053
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