BEGIN:VCALENDAR
VERSION:2.0
PRODID:icalendar-ruby
CALSCALE:GREGORIAN
METHOD:PUBLISH
BEGIN:VTIMEZONE
TZID:Europe/Vienna
BEGIN:DAYLIGHT
DTSTART:20190331T030000
TZOFFSETFROM:+0100
TZOFFSETTO:+0200
RRULE:FREQ=YEARLY;BYDAY=-1SU;BYMONTH=3
TZNAME:CEST
END:DAYLIGHT
BEGIN:STANDARD
DTSTART:20191027T020000
TZOFFSETFROM:+0200
TZOFFSETTO:+0100
RRULE:FREQ=YEARLY;BYDAY=-1SU;BYMONTH=10
TZNAME:CET
END:STANDARD
END:VTIMEZONE
BEGIN:VEVENT
DTSTAMP:20260404T065916Z
UID:5d400e0c07a76674475669@ist.ac.at
DTSTART:20190812T130000
DTEND:20190812T140000
DESCRIPTION:Speaker: Elias Barriga\nhosted by Michael Sixt\nAbstract: Colle
 ctive cell migration is essential for embryogenesis\, tissue repair and ca
 ncer metastasis. In order to successfully reach their destinations\, cells
  need to know when and where to migrate. During the last years a comprehen
 sive framework about how molecular signalling contribute to trigger and di
 rect cell migration has been generated. However\, when migrating across co
 mplex in vivo environments\, cells do not only interact with molecular cue
 s. Indeed\, cells are also expose to the mechanical nature of their migrat
 ory environment\, which based on in vitro experiments it is very likely to
  also contribute to cell migration. Though interesting as an observation\,
  whether and how mechanical inputs from the migratory substrate contribute
  to collective cell migration in vivo remained as an open question\, mostl
 y due to technical challenges.  During my postdoc\, I developed a toolbox 
 that allows to measure and modify the mechanical environment of living tis
 sues. Along my talk I will show how I used this toolbox to demonstrate tha
 t environmental mechanics first trigger and then direct the collective mig
 ration of Xenopus laevis cranial neural crest cells an embryonic cell popu
 lation that collectively migrates long distances across developing embryos
 . Overall\, the results that I will show support the idea that synchronisa
 tion of morphogenetic events\, such as cell migration\, not only require m
 olecular signalling but certainly\, such a synchronisation also requires f
 ine-tuning of the mechanical properties of the environment.
LOCATION:Mondi Seminar Room 1\, Central Building\, ISTA
ORGANIZER:astawick@ist.ac.at
SUMMARY:Elias Barriga: Mechanical Control of Collective Cell Migration in v
 ivo
URL:https://talks-calendar.ista.ac.at/events/2048
END:VEVENT
END:VCALENDAR