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DTSTART:20190331T030000
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DTSTART:20191027T020000
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BEGIN:VEVENT
DTSTAMP:20260404T041529Z
UID:5d2ec8174fb60257185178@ist.ac.at
DTSTART:20190719T150000
DTEND:20190719T163000
DESCRIPTION:Speaker: Stefan Münster\nhosted by Carl-Philipp Heisenberg\nAb
 stract: Gastrulation is a critical step during the development of multicel
 lular organisms in which a single-layered tissue folds into a multi-layere
 d germband. This shape change is characterized by tissue folding and large
 -scale tissue flow. The myosin-dependent forces that underlie this process
  have been increasingly investigated\; however\, thus far\, the possible i
 nteraction between the moving tissue and the rigid shell surrounding the e
 mbryo has been neglected. In this talk\, I will present our quantitative f
 indings on the physical mechanisms governing gastrulation in the red flour
  beetle (Tribolium castaneum). We investigated the forces expected within 
 the tissue given the myosin distribution observed by multi-view light-shee
 t microscopy and discovered that an additional external force must be coun
 teracting this tissue-intrinsic contractility. We then identified that a s
 pecific part of the tissue tightly adheres to the outer rigid shell.  This
  attachment is mediated by a specific integrin (Inflated) whose knock-down
  leads to a complete loss of the counter-force. Moreover\, in the fruit fl
 y (Drosophila melanogaster) knock-down of another integrin (Scab) leads to
  a severe twist of the germband\, suggesting that the integrin-mediated in
 teraction between tissue and vitelline envelope may be an important mechan
 ism that contributes a thus far unknown force to gastrulation movements in
  insects in general.
LOCATION:Mondi Seminar Room 2\, Central Building\, ISTA
ORGANIZER:lalesch@ist.ac.at
SUMMARY:Stefan Münster: An integrin-mediated adhesion between embryonic ti
 ssue and vitelline membrane affects gastrulation of insects
URL:https://talks-calendar.ista.ac.at/events/2034
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