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DTSTAMP:20260404T145219Z
UID:5d00a0696444d628282972@ist.ac.at
DTSTART:20190716T140000
DTEND:20190716T150000
DESCRIPTION:Speaker: Sebastian Maurer\nhosted by Martin Loose\nAbstract: Cy
 toplasmic mRNA transport on microtubules and local translation are essenti
 al for the spatial control of gene expression. In mammalian neurons\, mRNA
  localization is required for essential processes as axonal growth-cone st
 eering\, cell migration and synaptic plasticity underlying long-term memor
 y formation. Decades of research revealed several components involved in m
 ammalian mRNA transport processes. However\, which factors are essential a
 nd how they act in concert to produce the required mRNA distributions is n
 ot clear. Using biochemical in vitro reconstitutions in combination with f
 ast\, single-molecule sensitivity fluorescent imaging we show that the tum
 or suppressor adenomatous polyposis coli (APC) functions as adaptor linkin
 g the axonally localized beta-actin and beta-tubulin mRNAs to the heterotr
 imeric kinesin-2 KIF3A/B/KAP3. We demonstrate that the kinesin-2 cargo-ada
 ptor KAP3 is required to couple APC-RNA complexes to the motor protein\, w
 hile APC activates transport by recruiting the kinesin to microtubules. Re
 markably\, our minimal in vitro system shows that two proteins are suffici
 ent for processive mRNA transport and also to generate key-characteristics
  of neuronal mRNA transport as mRNA-cargo specificity and transport of def
 ined numbers of mRNAs. We further demonstrate that guanine-rich sequences 
 increase mRNA transport efficiency and balance the access of different mRN
 As to the transport system to compensate for relative mRNA abundance. Our 
 results reveal for the first time a minimal set of proteins sufficient to 
 drive kinesin-based\, mammalian mRNA transport.
LOCATION:Mondi Seminar Room 2\, Central Building\, ISTA
ORGANIZER:rsix@ist.ac.at
SUMMARY:Sebastian Maurer: A reconstituted mammalian mRNA transport system s
 electively transports defined amounts of axonal mRNAs
URL:https://talks-calendar.ista.ac.at/events/2012
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