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DTSTAMP:20260404T041023Z
UID:5cff5a4ba8cda419203501@ist.ac.at
DTSTART:20190617T130000
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DESCRIPTION:Speaker: Jan Lammerding\nhosted by Michael Sixt\nAbstract: The 
 nucleus is the characteristic feature of eukaryotic cells and houses the g
 enomic information of the cell. The Lammerding laboratory is combining cel
 l and molecular biology approaches with tissue engineering and microfabric
 ation techniques\, live-cell microscopy\, and in vivo models to investigat
 e the interplay between nuclear structure\, mechanics\, and function. In p
 articular\, the research is addressing how physical forces acting on the n
 ucleus\, for example\, in contracting muscle cells or during migration of 
 cells through tight interstitial spaces\, can challenge the integrity of t
 he nucleus\, alter its structure\, and cause genomic and transcriptional c
 hanges. I will present recent findings that demonstrate the importance of 
 nuclear mechanics during cell migration in confined environments in vitro 
 and in vivo\, as well as the functional consequences of cells having to sq
 ueeze their large nuclei through tight interstitial spaces and small pores
  in the extracellular matrix network. In addition\, I will discuss recent 
 findings that highlight the importance of the nuclear envelope proteins la
 mins A/C in mediating nuclear stability and mechanotransduction in mechani
 cally stressed cells and tissues\, including how lamin mutations result in
  reduced nuclear stability\, increased nuclear damage in striated muscle c
 ells\, and DNA damage and activation of DNA damage response pathways\, whi
 ch may explain the tissue-specific defects in diseases caused by lamin mut
 ations. Insights gained from these studies could improve prognostic approa
 ches and motivate novel therapeutic approaches for these diseases.
LOCATION:Mondi Seminar Room 3\, Central Building\, ISTA
ORGANIZER:astawick@ist.ac.at
SUMMARY:Jan Lammerding: Squish and squeeze: Nuclear mechanics in physiology
  and disease
URL:https://talks-calendar.ista.ac.at/events/2006
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