BEGIN:VCALENDAR
VERSION:2.0
PRODID:icalendar-ruby
CALSCALE:GREGORIAN
METHOD:PUBLISH
BEGIN:VTIMEZONE
TZID:Europe/Vienna
BEGIN:DAYLIGHT
DTSTART:20190331T030000
TZOFFSETFROM:+0100
TZOFFSETTO:+0200
RRULE:FREQ=YEARLY;BYDAY=-1SU;BYMONTH=3
TZNAME:CEST
END:DAYLIGHT
BEGIN:STANDARD
DTSTART:20191027T020000
TZOFFSETFROM:+0200
TZOFFSETTO:+0100
RRULE:FREQ=YEARLY;BYDAY=-1SU;BYMONTH=10
TZNAME:CET
END:STANDARD
END:VTIMEZONE
BEGIN:VEVENT
DTSTAMP:20260406T042004Z
UID:5cd13cc98a06d594052394@ist.ac.at
DTSTART:20190521T133000
DTEND:20190521T143000
DESCRIPTION:Speaker: Eva Kiermaier\nhosted by Michael Sixt\nAbstract: Centr
 osomes function as the major microtubule-organizing center in most animal 
 cells. They promote the assembly of the bipolar mitotic spindle\, which se
 gregates sister chromatids into two daughter cells. To assure spindle bipo
 larity\, centrosome duplication is precisely controlled and limited to onc
 e per cell cycle. Defects during the duplication cycle lead to centrosome 
 amplification  a hallmark of almost all solid tumors and hematological mal
 ignancies. To allow cancer cells to proceed through mitosis despite their 
 surplus of centrosomes\, excess centrosomes tightly cluster into a pseudo-
 bipolar spindle configuration. Novel classes of anti-cancer therapies indu
 ce centrosome de-clustering thus driving malignant cells into a multipolar
  mitosis and subsequent cell death. Similarly to cancer cell\, primary den
 dritic cells\, which are the most potent antigen presenting cells of the i
 nnate immune system\, exhibit an increased number of centrosomes. Excess c
 entrosomes cluster during migration and pharmacological induction of centr
 osome de-clustering leads to polarization defects and loss of directed cel
 l migration. Our data indicate that amplified centrosomes are not only a m
 arker for malignancy but actually promote immune cell effector functions s
 uch as antigen presentation and T cell activation. We are further interest
 ed in the molecular basis of how amplified centrosomes enhance immune resp
 onses\, which will critically impact the use of centrosome-based cancer th
 erapies.
LOCATION:Mondi Seminar Room 2\, Central Building\, ISTA
ORGANIZER:akopf@ist.ac.at
SUMMARY:Eva Kiermaier: Function and Regulation of Centrosomes during Immune
  Responses
URL:https://talks-calendar.ista.ac.at/events/1987
END:VEVENT
END:VCALENDAR