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DTSTART:20190331T030000
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DTSTART:20191027T020000
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DTSTAMP:20260405T192627Z
UID:5c82a14b929ea078323143@ist.ac.at
DTSTART:20190514T133000
DTEND:20190514T143000
DESCRIPTION:Speaker: Sergi Simo\nhosted by Simon Hippenmeyer\nAbstract: Dur
 ing Central Nervous System development\, neurons migrate\, mature\, and in
 tegrate into the following an intricate set of cues. Similarly\, in the a
 dult brain\, homeostasis is achieved by responding to cues that regulate a
  myriad of processes\, including adult neurogenesis. Cells respond to all 
 these cues by triggering signaling pathways that\, once the information is
  transduced\, must be downregulated. Inappropriate regulation of signalin
 g pathways cause neurons to mismigrate\, lose responsiveness to new signal
 s\, and/or sustain the original signaling response\, causing harm or deat
 h to the cell. The E3 Cullin-5 RING ligase (CRL5) is a crucial regulator 
 of neuron migration and cell position in the retina\, cortex\, and cerebel
 lum\, by downregulating the Reelin/Dab1 signaling pathway. However\, the 
 role of CRL5 in the developing and adult hippocampus has remained elusive
 . Our work shows that CRL5 regulates lamination of hippocampal pyramidal n
 eurons and participates in their dendritic arborization. We uncover that 
 CRL5 downregulation of the small GTPase ARL4C\, and its associated signal
 ing effectors\, participates in pyramidal neuron apical dendrite and dendr
 itic tree formation and potentially in pyramidal neuron localization duri
 ng hippocampal development. Moreover\, CRL5 participates in dentate gyrus
  lamination and mossy fiber (i.e. granule cell axon) innervation. Particul
 arly\, we showed that depletion of Rbx2 affects mossy fiber pruning by de
 regulating the Semaphorin-3F signaling. Finally\, we show that CRL5 also 
 opposes Reelin/Dab1 signaling in the hippocampus to restrain the productio
 n of adult-born neurons in the dentate gyrus. Overall\, we identified CRL
 5 as a novel regulator of hippocampal morphogenesis and homeostasis and u
 ncovered several CRL5-regulated signaling pathways involved in these even
 ts.
LOCATION:Seminar Room\, Lab Building East\, ISTA
ORGANIZER:lmarr@ist.ac.at
SUMMARY:Sergi Simo: The Importance of Signaling Pathway Downregulation for 
 Central Nervous System Development and Homeostasis
URL:https://talks-calendar.ista.ac.at/events/1978
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