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DTSTART:20190331T030000
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DTSTART:20191027T020000
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DTSTAMP:20260405T192613Z
UID:5cc2e3c6a3a0e870494205@ist.ac.at
DTSTART:20190506T110000
DTEND:20190506T121500
DESCRIPTION:Speaker: Nikhil Mishra\nhosted by Carl-Philipp Heisenberg\nAbst
 ract: During Caenorhabditis elegans development\, 131 somatic cells invari
 ably die in acontrolled manner. Most of these cells die through a process 
 called apoptosis and arethe smaller daughter of a mother cell that divides
  asymmetrically. In animals with areduced asymmetry of the mother cell div
 ision\, the apoptotic fate is often notsuccessfully executed\, which resul
 ts in the presence of extra cells. Thus\, asymmetriccell division (ACD) an
 d cell fate specification and execution (including apoptosis) arefunctiona
 lly linked. However\, while the influence of ACD on daughter cell fate has
  beenwidely investigated\, it remains unclear if the factors that determin
 e daughter cell fatealso\, in turn\, govern ACD. During my PhD\, I discove
 red a novel role of the C. eleganscentral apoptotic pathway in promoting a
 symmetry in divisions of mother cells thatproduce apoptotic daughters. I f
 ound that proapoptotic genes not only ensure that theapoptotic cells are s
 maller in size but also that they inherit limited amounts of promitoticfac
 tors. This role is dependent on the protease function of CED-3 caspase. We
  havenow identified ect-2\, which encodes a Rho-GEF\, as an interactor of 
 ced-3. Our resultssuggest that ect-2 acts downstream of ced-3 and that it 
 may mediate the regulation ofACD by ced-3. Preliminary results indicate th
 at anisotropic actomyosin contractility inthe mother cell may govern its a
 symmetric division\, and\, being a positive regulator ofactomyosin contrac
 tility\, ect-2 is well-placed to facilitate the regulation of ACD by ced-3
 .In my talk\, I will discuss the results we have obtained in our attempts 
 to explore thispotential CED-3-Myosin interaction mediated by ECT-2 in the
  context of asymmetric celldivision.
LOCATION:Meeting room 2nd floor / Bertalanffy Bldg. (I04.2OG - LAB)\, ISTA
ORGANIZER:lalesch@ist.ac.at
SUMMARY:Nikhil Mishra: Potential caspase-myosin interaction as a regulator 
 of asymmetric cell division in Caenorhabditis elegans
URL:https://talks-calendar.ista.ac.at/events/1963
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