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DTSTART:20190331T030000
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DTSTART:20191027T020000
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DTSTAMP:20260403T220439Z
UID:5cbebd7cc1721957848450@ist.ac.at
DTSTART:20190524T163000
DTEND:20190524T180000
DESCRIPTION:Speaker: Hitoshi Okamoto\nhosted by Ryuichi Shigemoto\nAbstract
 : The fish brains are anatomically by far more similar to the mammalian br
 ains than people used to think. Taking advantage of this evolutionary cons
 ervation and its structural simplicity\, we have been studying zebrafish b
 rain to elucidate the mechanism of two aspects of adaptive brain functions
 \, i.e. resolution of social conflict and decision making.The habenula (Hb
 ) is an evolutionarily conserved diencephalic structure. We discovered tha
 t the dorsal and ventral Hb (dHb and vHb) of zebrafish correspond respecti
 vely to the medial and lateral regions of mammalian Hb. We have recently f
 ound that the two subregions of the dorsal habenula (dHb) in zebrafish ant
 agonistically regulate the outcome of conflict. We now show the evidence t
 hat the habenula plays the evolutionarily conserved roles in the resolutio
 n of social conflict in mammals.We also use adult zebrafish as a model ani
 mal for the study of decision making in visual-based active avoidance task
 s by establishing the closed-loop virtual reality (VR) system for the head
 -tethered adult zebrafish with the 2-photon calcium imaging system. We hav
 e identified two ensembles of neural activities which encode the different
  aspects of prediction errors between the status represented by the real s
 ensory inputs and the favorable status to achieve to successfully escape f
 rom the danger\, i.e. visual inputs of the backward moving landscape and t
 he wall color of the goal compartment\, and observed that the behaviors ar
 e taken so that these errors become minimum. Our results show that the adu
 lt zebrafish behaves in decision making based on the behavioral rule calle
 d active inference\, where agents take actions to suppress the prediction 
 errors by trying to make the internal representations of the bottom-up sen
 sory states best match those of the top-down predictions\, and have demons
 trated the strong conservation of the basic principle of decision making t
 hroughout the evolution.
LOCATION:I22 Lakeside View (I22.01)\, ISTA
ORGANIZER:lmarr@ist.ac.at
SUMMARY:Hitoshi Okamoto: Dissecting our mind based on evolutionary conserva
 tion
URL:https://talks-calendar.ista.ac.at/events/1957
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