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DTSTART:20190331T030000
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DTSTART:20191027T020000
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BEGIN:VEVENT
DTSTAMP:20260405T175503Z
UID:5cb47b99025a4095081516@ist.ac.at
DTSTART:20190423T160000
DTEND:20190423T170000
DESCRIPTION:Speaker: Milos Stanojlovic\nhosted by Ryuichi Shigemoto\nAbstra
 ct: Parkinsons disease (PD) is a multi-layered progressive neurodegenerati
 ve disease with heterogeneous symptomology. Signature motor system impairm
 ents are accompanied by a variety of other symptoms such as mood\, sleep\,
  metabolic and cognitive disorders. Interestingly\, the non-motor impairme
 nts can be observed from the earliest stages of the disease\, prior to the
  onset of the motor symptoms. In these series of studies early and age-rel
 ated cognitive\, mood and metabolic disorders in A53T mouse model of PD we
 re observed. As inflammation and astrogliosis are an integral part of PD p
 athology and impair proper neuronal function\, affecting behavior and meta
 bolism\, astrogliosis and inflammation markers were examined in different 
 brain regions. Finally\, DREADDs (Designer Receptors Exclusively Activated
  by Designer Drugs) were used for the stimulation and inhibition of orexin
  neuronal activity (hypothalamic neuronal subpopulation involved in regula
 tion of mood\, cognition and metabolism) to modulate various aspects of be
 havior and metabolism in A53T mice. Observed behavioral and metabolic impa
 irments in A53T mice are accompanied by an increase in astrogliosis and in
 flammation markers and neuronal loss. Moreover\, chemogenetic modulation o
 f orexin neuronal activity shows to be powerful tool for modulation of beh
 avior and metabolism in A53T model of PD.
LOCATION:Seminar Room\, Lab Building East\, ISTA
ORGANIZER:shigemot@ist.ac.at
SUMMARY:Milos Stanojlovic: Chemogenetic modulation of orexin/hypocretin neu
 ronal activity ameliorates cognitive\, behavioral and metabolic impairment
 s in A53T mouse model of Parkinson`s disease
URL:https://talks-calendar.ista.ac.at/events/1928
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