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TZID:Europe/Vienna
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DTSTART:20190331T030000
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DTSTART:20191027T020000
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DTSTAMP:20260404T015840Z
UID:5c3c564a2a5da166198433@ist.ac.at
DTSTART:20190405T110000
DTEND:20190405T120000
DESCRIPTION:Speaker: Laurent Nguyen\nhosted by Simon Hippenmeyer\nAbstract:
  Interneurons navigate along multiple tangential paths to settle into appr
 opriate cortical layers. They undergo a saltatory migration paced by inter
 mittent nuclear jumps whose regulation relies on interplay between extrace
 llular cues and genetic-encoded information. However\, it remains unclear 
 how cycles of pause and movement are coordinated at the molecular level. P
 ost-translational modification of proteins contributes to cell migration r
 egulation. The present study uncovers that carboxypeptidase 1 (CCP1)\, whi
 ch promotes posttranslational protein deglutamylation\, controls the pausi
 ng of migrating cortical interneurons. Moreover\, we demonstrate that paus
 ing during migration attenuates movement simultaneity at the population le
 vel thereby controlling the flow of interneurons invading the cortex. Inte
 rfering with the regulation of pausing not only affects the size of the co
 rtical interneuron cohort but also impairs the generation of age-matched p
 rojection neurons of the upper layers. Importantly\, several CCP1 variants
  have been discovered in patients suffering from brain malformation and ou
 r follow up work is to understand how these variant interfere with CCP1 fu
 nction in brain development.
LOCATION:Seminar Room\, Lab Building East\, ISTA
ORGANIZER:lmarr@ist.ac.at
SUMMARY:Laurent Nguyen: Cell migration promotes dynamic cellular interactio
 ns to control cerebral cortex morphogenesis
URL:https://talks-calendar.ista.ac.at/events/1881
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