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DTSTART:20190331T030000
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DTSTART:20181028T020000
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DTSTAMP:20260406T042009Z
UID:5c8a6fde0b79f426016165@ist.ac.at
DTSTART:20190325T140000
DTEND:20190325T150000
DESCRIPTION:Speaker: Jéssica Cristina Coelho Gaspar\nhosted by Ryuichi Shi
 gemoto\nAbstract: Peroxisome proliferator-activated receptors (PPARs) are 
 nuclear receptors. There is evidence for their involvement in pain\, cogni
 tion\, and anxiety. However\, their role in pain-fear interactions is unkn
 own. The aim of the research was to investigate the effects of the systemi
 c and intra-basolateral amygdala (BLA) and central amygdala (CeA) administ
 ration of PPARa\, PPARb/d and PPARg antagonists on nociceptive behaviour\,
  fear-conditioned analgesia (FCA)\, conditioned fear\, anxiety and cogniti
 on in presence or absence of nociceptive tone in rats.Systemic administrat
 ion of all antagonists potentiated context-induced freezing in the presenc
 e of a formalin-evoked nociceptive tone\, with no effect on nociceptive be
 haviour. Intra-BLA\, but not intra-CeA\, administration of PPARa or PPARg 
 antagonists potentiated freezing in the presence of nociceptive tone in FC
  rats. Blockade of all PPARs in the BLA\, but not in the CeA\, increased f
 reezing and BLA dopamine levels in NFC rats in the absence of nociceptive 
 tone. Formalin-injected FC rats receiving intra-BLA PPARa and PPARg antago
 nists had higher levels of dopamine in the BLA. Systemic administration of
  PPAR antagonists do not seem to change anxiety-related or cognitive-relat
 ed behaviour.  
LOCATION:Seminar Room\, Lab Building East\, ISTA
ORGANIZER:lmarr@ist.ac.at
SUMMARY:Jéssica Cristina Coelho Gaspar: Differential role of amygdalar PPA
 Rs in conditioned fear\, anxiety and cognitive behaviour in the presence a
 nd absence of nociceptive tone
URL:https://talks-calendar.ista.ac.at/events/1874
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