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DTSTART:20160327T030000
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DTSTART:20161030T020000
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DTSTAMP:20260429T024525Z
UID:57209db7e4d86673746965@ist.ac.at
DTSTART:20161017T160000
DTEND:20161017T171500
DESCRIPTION:Speaker: Ryohei Yasuda\nAbstract: Activity-dependent changes in
  synaptic strength and structure are believed to be cellular basis of lear
 ning and memory. A cascade of biochemical reaction in dendritic spines\, t
 iny postsynaptic compartments emanating from dendritic surface\, underlies
  diverse forms of synaptic plasticity. The reaction in dendritic spines is
  mediated via signaling networks consist of hundreds of species of protein
 s. We have developed unique optical techniques to elucidate the operation 
 principles of such signaling networks. First\, based on 2-photon fluoresce
 nce lifetime imaging and highly sensitive biosensors\, we have developed t
 echniques to image signaling activity in single dendritic spines. We have 
 succeeded in monitoring activity of several key signaling proteins in sing
 le spines undergoing structural and functional plasticity. This provided n
 ew insights into how the spatiotemporal dynamics of signaling are organize
 d during synaptic plasticity. We have developed sensitive and specific sen
 sors for CaMKI\, CaMKII\, Rho GTPase proteins\, Rab GTPase proteins\, prot
 ein kinase C isozymes (?\, ?\, ? etc) and a BDNF receptor TrkB. By monitor
 ing signaling components with high spatiotemporal resolution\, we expect t
 o reveal the mechanisms underlying the spatiotemporal regulation of signal
 ing dynamics underlying synaptic plasticity and learning and memory.\n
LOCATION:Raiffeisen Lecture Hall\, Central Building\, ISTA
ORGANIZER:aeller@ist.ac.at
SUMMARY:Ryohei Yasuda: The Institute Colloquium: Signal transduction in sin
 gle dendritic spines
URL:https://talks-calendar.ista.ac.at/events/185
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