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DTSTART:20190331T030000
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DTSTART:20181028T020000
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DTSTAMP:20260405T215652Z
UID:5c6ecaf5cf5d6191041423@ist.ac.at
DTSTART:20190318T133000
DTEND:20190318T143000
DESCRIPTION:Speaker: Chase Broedersz\nAbstract: In many biological phenomen
 a\, cells migrate through confining structured environments. We study how 
 migrating cells overcome physical obstacles in the form of a thin constric
 tion. Specifically\, we ask whether such confined migration exhibits emerg
 ent stochastic dynamical laws. To this end\, we develop two-state micropat
 terns\, consisting of two adhesive sites connected by a thin constriction\
 , allowing the cells to perform repeated stochastic transitions between th
 e sites. For this minimal system\, we obtain a large data set of single ce
 ll trajectories\, enabling us to infer an equation of cell motion\, which 
 decomposes the dynamics into deterministic and stochastic contributions. O
 ur data-driven approach reveals that these cells exhibit intricate non-lin
 ear migratory dynamics\, with qualitatively similar features for cancerous
  (MDA-MB-231) and non-cancerous (MCF10A) cells. In both cases\, the cells 
 drive themselves deterministically into the thin constriction\, a process 
 that is sped up by noise. Interestingly\, the deterministic dynamics of th
 e cancerous cells exhibits a limit cycle\, while the non-cancerous cells s
 how excitable bistable dynamics.
LOCATION:Mondi Seminar Room 3\, Central Building\, ISTA
ORGANIZER:dboocock@ist.ac.at
SUMMARY:Chase Broedersz: Dynamics of Confined Cell Migration
URL:https://talks-calendar.ista.ac.at/events/1834
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