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DTSTART:20190331T030000
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DTSTART:20181028T020000
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DTSTAMP:20260405T192026Z
UID:5c6a9ed27921d795016494@ist.ac.at
DTSTART:20190305T100000
DTEND:20190305T110000
DESCRIPTION:Speaker: Paul Schanda\nhosted by Florian Schur\nAbstract: Livin
 g systems are inherently dynamic\, and the motions and flexibility of the 
 underlying molecular actors\, biopolymers\, are the basis for all biologic
 al processes. NMR spectroscopy is exquisitely sensitive to dynamics\, and 
 provides functional insights beyond static structures. We combine solution
 - and solid-state NMR\, (cryo-)EM\, MD simulations\, X-ray and in-vivo exp
 eriments to address questions ranging from fundamental biophysics to biolo
 gical mechanisms.Along with new NMR methodologies\, I will address fundame
 ntal aspects of protein dynamics: how do proteins exchange between various
  functional states? Are their motions preserved when trapped in crystal la
 ttices? How and at which temperature are motions activated? I introduce an
  approach that combines NMR and cryo-EM to obtain atomic-level 3D structur
 es\, and show its application to a 0.5 MDa-large aminopeptidase enzyme. Be
 yond structure\, I show how dynamics control the function of this large en
 zymatic machinery.Finally\, I will present recent insight into the mechani
 sms of molecular chaperones\, focusing in particular on the mechanisms by 
 which chaperones transport highly aggregation-prone membrane proteins into
  mitochondria.
LOCATION:Mondi Seminar Room 2\, Central Building\, ISTA
ORGANIZER:tguggenb@ist.ac.at
SUMMARY:Paul Schanda: From dynamic biomolecular structures to biological fu
 nction using integrated NMR-based structural biology
URL:https://talks-calendar.ista.ac.at/events/1813
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