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DTSTART:20190331T030000
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DTSTART:20181028T020000
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DTSTAMP:20260404T110038Z
UID:5c48a9637b1d0947378380@ist.ac.at
DTSTART:20190219T110000
DTEND:20190219T121500
DESCRIPTION:Speaker: Prisca Liberali\nhosted by Edouard Hannezo\nAbstract: 
 Intestinal organoids are complex three-dimensional structures that mimic c
 ell type composition and tissue organization of the intestine by recapitul
 ating the self-organizing capacity of cell populations derived from a sing
 le stem cell. Crucial in this process is a first symmetry-breaking event\,
  in which only a fraction of identical cells in a symmetrical sphere diffe
 rentiate into Paneth cells\, which in turn generates the stem cell niche a
 nd leads to asymmetric structures such as crypts and villi. We here combin
 e a quantitative imaging approach with single-cell gene expression to char
 acterize the development of intestinal organoids from a single cell. We sh
 ow that intestinal organoid development follows a regeneration process dri
 ven by transient Yap1 activation.  Cell-to-cell variability in Yap1\, emer
 ging in symmetrical spheres\, initiates a Notch/Dll1 lateral inhibition ev
 ent driving the symmetry-breaking event and the formation of the first Pan
 eth cell. Our findings reveal how single cells exposed to a uniform growth
 -promoting environment have the intrinsic ability to generate emergent\, s
 elf-organized behavior resulting in the formation of complex multicellular
  asymmetric structures.
LOCATION:Mondi Seminar Room 3\, Central Building\, ISTA
ORGANIZER:channezo@ist.ac.at
SUMMARY:Prisca Liberali: Self-organization and symmetry breaking in intesti
 nal organoid development
URL:https://talks-calendar.ista.ac.at/events/1804
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