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DTSTART:20190331T030000
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DTSTART:20181028T020000
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DTSTAMP:20260406T041134Z
UID:5c485311ad4d8641486317@ist.ac.at
DTSTART:20190227T100000
DTEND:20190227T110000
DESCRIPTION:Speaker: Lora Sweeney\nhosted by Gaia Novarino\nAbstract: Motor
  output varies along the rostro-caudal axis of the spinal cord. At limb le
 vels\, pairs of muscles flex and extend about each joint to coordinate run
 ning and grasping. In contrast\, at thoracic levels\, torso muscles suppor
 t posture\, inspiration and expiration. In both the developing mouse and X
 enopus frog\, I have investigated how these differences in motor complexit
 y along the body axis are reflected in the cell type diversity of inhibito
 ry neurons. In the mouse\, I applied a combination of transcription factor
  profiling\, Bayesian analysis\, and machine-learning to define limb- and 
 thoracic-specific inhibitory cell types. In the frog\, I determined whethe
 r the limb- and thoracic- inhibitory cell types I identified are conserved
  across species and scale with motor behavior as tadpoles transition from 
 swimming to walking. My studies support that molecularly-distinct inhibito
 ry subpopulations exist to subserve limb and thoracic movement across spec
 ies.
LOCATION:Mondi Seminar Room 2\, Central Building\, ISTA
ORGANIZER:tguggenb@ist.ac.at
SUMMARY:Lora Sweeney: Defining inhibitory microcircuits for limb and thorac
 ic movement
URL:https://talks-calendar.ista.ac.at/events/1776
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