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DTSTART:20190331T030000
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DTSTART:20181028T020000
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DTSTAMP:20260406T182358Z
UID:5c482e02a8f0c929142226@ist.ac.at
DTSTART:20190206T160000
DTEND:20190206T173000
DESCRIPTION:Speaker: Vignjevic Danijela\nhosted by Kasumi Kishi\nAbstract: 
 The entire intestinal epithelium is renewed every week due to cell divisio
 n in the crypts coupled with cell migration towards the villi and loss of 
 cells by apoptosis at the tip of villi. However\, the mechanism responsibl
 e for the migration of intestinal cells remains largely unknown. Using tra
 nsgenic animals\, ex vivo gut slice cultures and theoretical modeling\, we
  found that in the crypts\, epithelial cells move passively as a consequen
 ce of the pushing force generated by dividing cells. However\, along the v
 illi\, cells move actively using actomyosin-rich basal cellular protrusion
 s.In the second part of the talk I will talk about the role of tumor micro
 environment in the tumor progression. It is made of extracellular matrix (
 ECM)\, blood vessels\, immune cells and cancer-associated fibroblasts (CAF
 s). Besides biochemical signals\, mechanical forces from microenvironment 
 also play a role in tumor progression. CAFs have enhanced contractility an
 d capacity to synthesize\, deposit and crosslink ECM making stroma stiffer
 . Thus\, by accumulating around the tumor\, they could provide a physical 
 barrier constraining tumor expansion. However\, it has been shown that by 
 exerting mechanical forces on the ECM\, CAFs also enhance tumor invasion. 
 These antagonistic roles of forces produced by CAFs in tumor progression w
 ill be discussed.
LOCATION:Mondi Seminar Room 3\, Central Building\, ISTA
ORGANIZER:lalesch@ist.ac.at
SUMMARY:Vignjevic Danijela: Cell migration in gut homeostasis and cancer in
 vasion - role of microenvironment
URL:https://talks-calendar.ista.ac.at/events/1774
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