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DTSTART:20190331T030000
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DTSTAMP:20260405T154436Z
UID:5c3dfa48374a5704411125@ist.ac.at
DTSTART:20190123T130000
DTEND:20190123T141500
DESCRIPTION:Speaker: Steve Abedon\nhosted by Claudia Igler\nAbstract: Bacte
 riophages are viruses of bacteria. The concept of inter-cellular communica
 tion among viruses has been recently rediscovered in the guise of small-mo
 lecule-based mechanisms\, dubbed arbitrium systems (ASs). These are expres
 sed by some Bacillus subtilis phages. Even more recently\, a phage has bee
 n identified which is able to recognize and respond to Vibrio cholerae quo
 rum-sensing signal molecules. In both cases\, what is observed are modific
 ations of the timing of phage-induced bacterial lysis. With ASs\, phage-in
 duced bacterial lysis is delayed. That is\, phage lysogenic cycles rather 
 than lytic cycles are displayed when phage-infection-produced signaling mo
 lecules are present\, in the environment\, at relatively high concentratio
 ns. With the V. cholerae system\, lysis instead is accelerated\, with prop
 hages induced when a bacterium-encoded quorum-sensing signal (autoinducer)
  is present\, also at relatively high densities. Quorum-sensing system gen
 e homologs have also been found in a Clostridium difficile phage genome. I
 n a general sense\, many or all of these mechanisms can be described as ex
 amples of phage social behaviors that result in a phenotypic plasticity in
  phage lysis timing. Notwithstanding these newly discovered systems\, howe
 ver\, virus-virus communication was first discovered over 70 years ago. I 
 will consider the ecology of these and other mechanisms of virus-virus int
 ercellular communication\, including my own work in this area studying bac
 teriophage T4 of Escherichia coli.
LOCATION:Meeting room 1st floor / Central Bldg. (I01.1OG - Zentralgebäude)
 \, ISTA
ORGANIZER:cigler@ist.ac.at
SUMMARY:Steve Abedon: Look Who’s Talking: Bacteriophage Inter-Cellular Com
 munication (A Current but Not so New Field of Study)
URL:https://talks-calendar.ista.ac.at/events/1765
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