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DTSTAMP:20260404T110208Z
UID:5c330b2e8623f602023963@ist.ac.at
DTSTART:20190114T110000
DTEND:20190114T120000
DESCRIPTION:Speaker: Chuck Langley\nhosted by Nick Barton\; Beatriz Vicoso\
 nAbstract: Centromeres and their surrounding pericentric heterochromatic r
 egions remain enigmatic and poorly understood despite critical roles in eu
 karyotic inheritance.  Their vast size\, highly repetitive structure\, pau
 city of coding genes and low recombination rates have impeded genetic and 
 genomic advancement. Potentially large selective impacts of recurrent meio
 tic drive in female meiosis have been proffered as the causes of evolution
 arily rapid genomic 'turnover' centromere associated satellite DNAs.  The 
 epigenetic inheritance of the functional centromere and the growing catalo
 g of the genes/proteins and pathways essential to centromeres function all
  motivate a full accounting of genomic diversity in centromeric regions.  
 I shall report on identification of cenhaps\, large scale haplotypic varia
 tion in both humans and Drosophila that spans the complete centromerics re
 gions of metacentic chromosomes\, including the unassembled gaps in the re
 ference genomes that contain Mbp of highly repeated sequences (170 bp alph
 a-satellites in humans and smaller satellites in flies).  The inferred dyn
 amics behind the apparent descent of cenhaps are surprisingly rich and com
 plex\, including archaic lineages.  Variation among cenhaps in satellite D
 NA content is common\, opening a direct avenue to test hypotheses about th
 e mechanistic consequence of heterozygosity for large differences in 'cent
 romere strength' in mitosis and meiosis\, as well as to more precise model
 ing of their evolutionary dynamics.
LOCATION:Big Seminar room Ground floor / Office Bldg West (I21.EG.101)\, IS
 TA
ORGANIZER:ehacker@ist.ac.at
SUMMARY:Chuck Langley: Evolutionary genomics in centromeric and pericentrom
 eric regions of Drosophila and humans
URL:https://talks-calendar.ista.ac.at/events/1732
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