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DTSTART:20190331T030000
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DTSTART:20181028T020000
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DTSTAMP:20260405T161356Z
UID:5c265ad20c440853828222@ist.ac.at
DTSTART:20190124T100000
DTEND:20190124T110000
DESCRIPTION:Speaker: Felix Leroy\nhosted by Jozsef Csicsvari\nAbstract: Alt
 hough the hippocampus is known to be important for declarative memory\, it
  is less clear how hippocampal output regulates motivated behaviours\, suc
 h as social aggression. I will report that pyramidal neurons in the CA2 re
 gion of the hippocampus\, which are important for social memory\, promote 
 social aggression in mice. This action depends on output from CA2 to the l
 ateral septum\, which is selectively enhanced immediately before an attack
 . Activation of the lateral septum by CA2 recruits a circuit that disinhib
 its a subnucleus of the ventromedial hypothalamus that is known to trigger
  attack. The social hormone arginine vasopressin enhances social aggressio
 n by acting on arginine vasopressin 1b receptors on CA2 presynaptic termin
 als in the lateral septum to facilitate excitatory synaptic transmission. 
 In this manner\, release of arginine-vasopressin in the lateral septum\, d
 riven by an animals internal state\, may serve as a modulatory control tha
 t determines whether CA2 activity leads to declarative memory of a social 
 encounter and/or promotes motivated social aggression.
LOCATION:Mondi Seminar Room 2\, Central Building\, ISTA
ORGANIZER:tguggenb@ist.ac.at
SUMMARY:Felix Leroy: Hippocampal CA2 control of social behaviors.
URL:https://talks-calendar.ista.ac.at/events/1718
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