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DTSTART:20170326T030000
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DTSTART:20171029T020000
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DTSTAMP:20260428T112232Z
UID:57209db7e4de1111077446@ist.ac.at
DTSTART:20170410T160000
DTEND:20170410T171500
DESCRIPTION:Speaker: Claudia Bagni\nhosted by Gaia Novarino\nAbstract: One 
 fourth of the population is estimated to be affected by a mental or behavi
 oural disorder\, including schizophrenia (SCZ)\, autism spectrum disorder 
 (ASD) and intellectual disability (ID). These pathologies are typically as
 sociated with disturbed early neurodevelopment. CYFIP1 (Cytoplasmic FMRP I
 nteracting Protein 1) is a strong candidate gene for several mental disord
 ers. In humans the CYFIP1 gene is located on chromosome 15q11.2\, a highly
  unstable region associated to ASD\, SCZ and Epilepsy. In addition\, CYFIP
 1 has two important functions: (1) it binds the RNA-binding protein Fragil
 e X Mental Retardation Protein (FMRP) and (2) is part of the WAVE regulato
 ry complex involved in actin dynamics. Therefore\, CYFIP1 regulates local 
 protein synthesis and actin remodeling\, two key processes important for p
 roper synaptic function and development. During my lecture I will discuss 
 how using mouse and fly models as well patients’ cells\, we identified C
 YFIP1-mediated mechanisms involved in neuronal development and social beha
 viour. We propose that CYFIP1 may be a hub for different neurological and
  intellectual disability disorders.\n
LOCATION:Raiffeisen Lecture Hall\, Central Building\, ISTA
ORGANIZER:aeller@ist.ac.at
SUMMARY:Claudia Bagni: Brain wiring and social behaviour: Insights into aut
 ism and schizophrenia
URL:https://talks-calendar.ista.ac.at/events/17
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