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DTSTART:20190331T030000
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DTSTART:20181028T020000
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DTSTAMP:20260405T054112Z
UID:5c06623e0eb92236574097@ist.ac.at
DTSTART:20190306T130000
DTEND:20190306T140000
DESCRIPTION:Speaker: Bon-Kyoung Koo\nhosted by Ani Kicheva\nAbstract: The g
 astric corpus is comprised of a glandular epithelium that consists of func
 tionally specialized gastric cells\, secreting gastric acid\, peptidase\, 
 and mucin. Proliferating cells are often observed around the isthmus\, the
  upper middle part of gastric corpus glands. Based on the location of cell
  proliferation and nucleotide labeling experiments\, the adult gastric ste
 m cell population has been predicted to reside around the isthmus region o
 f the stomach. Recently\, Troy+ chief cells were found to have stem cell a
 ctivity at the base of the corpus glands. Troy+ chief cells are largely qu
 iescent so that the overall contribution of Troy+ chief cells to the norma
 l turnover of the tissue seems marginal. However\, different injury stimul
 i lead to an activation of this dormant stem cell population and an increa
 se in proliferation in the gland base. In order to understand the organiza
 tion and cellular hierarchy in the gastric corpus epithelium\, we utilized
  a novel lineage tracing strategy\, cell type specific depletion models\, 
 as well as gastric organoid cultures. Our results indicate that the homeos
 tatic tissue turnover of gastric corpus glands is simultaneously fueled by
  base and isthmus located stem cell populations. Gastric corpus glands fur
 thermore show a highly ordered epithelial structure which further constrai
 ns the behavioral dynamics of gastric stem cells in the isthmus compartmen
 t.
LOCATION:Mondi Seminar Room 2\, Central Building\, ISTA
ORGANIZER:akicheva@ist.ac.at
SUMMARY:Bon-Kyoung Koo: Two types of stomach stem cells for the homeostatic
  turnover of gastric corpus glands
URL:https://talks-calendar.ista.ac.at/events/1672
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