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DTSTART:20181028T020000
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DTSTAMP:20260404T065316Z
UID:5bfbd8c3a1e0f295346032@ist.ac.at
DTSTART:20181205T120000
DTEND:20181205T131500
DESCRIPTION:Speaker: Juergen A. Knoblich\nhosted by Simon Hippenmeyer\nAbst
 ract: The human brain is unique in size and complexity\, but also the sour
 ce of some of the most devastating human diseases. While many of these dis
 orders have been successfully studied in model organisms\, recent experime
 nts have emphasized unique features that can not easily be modeled in anim
 als. We have therefore developed a 3D organoid culture system derived from
  human pluripotent stem cells that recapitulates many aspects of human bra
 in development. These cerebral organoids are capable of generating several
  brain regions including a well-organized cerebral cortex. Furthermore\, h
 uman cerebral organoids display stem cell properties and progenitor zone o
 rganization that show characteristics specific to humans. We have used pat
 ient specific iPS cells to model microcephaly\, a human neurodevelopmental
  disorder that has been difficult to recapitulate in mice. This approach r
 eveals premature neuronal differentiation with loss of the microcephaly pr
 otein CDK5RAP2\, a defect that could explain the disease phenotype. More r
 ecently\, we have been able to generate organoid based models for human br
 ain cancer and demonstrated their feasibility for drug testing. Our data d
 emonstrate an in vitro approach that recapitulates development of even thi
 s most complex organ\, which can be used to gain insights into disease mec
 hanisms.
LOCATION:Mondi Seminar Room 2\, Central Building\, ISTA
ORGANIZER:lmarr@ist.ac.at
SUMMARY:Juergen A. Knoblich: Cerebral organoids: modelling human brain deve
 lopment and tumorigenesis in stem cell derived 3D culture
URL:https://talks-calendar.ista.ac.at/events/1635
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