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DTSTART:20190331T030000
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DTSTAMP:20260405T215643Z
UID:5bed779c9fccb590861385@ist.ac.at
DTSTART:20181120T160000
DTEND:20181120T173000
DESCRIPTION:Speaker: Ghanti Dipanwita\nhosted by Carl-Philipp Heisenberg\nA
 bstract: During cell division\, chromosome segregation is done by a comple
 x multicomponent machine known as spindle apparatus where microtubules (MT
 s) nucleate from the pole of the spindle and interact with different parts
  of the cell. During chromosome segregation in a mammalian cell\, the bund
 le of MTs collectively exert a force on the sister chromosomes pulling the
 se apart. We have developed a theoretical model of a bundle of parallel dy
 namic MTs where plus end of all the MTs in the bundle are permanently atta
 ched to a movable wall. In the absence of external force and direct latera
 l interactions between the MTs\, collective dynamics and indirect interact
 ions among the MTs give rise to the rich variety of motility states.Cell f
 unction is dependent on the formation and rupture of different kind of spe
 cific and nonspecific interactions. Strength and stability of these intera
 ctions can be studied by applying an external force on the attachment. The
  strength of the kinetochore-MT attachment can be investigated by applying
  an external tension that increases linearly with time until rupture occur
 s. Then we extend the model to mimic the kt-MT attachments where a bundle 
 of parallel MTs can simultaneously attach to a single kt. Also\, we have s
 tudied the strength and stability of another important attachment between 
 MT and cortex wall. Our stochastic kinetic model reveals that the MT-corte
 x attachment behaves as a catch bond.In addition to these cytoskeletal mot
 ors and microtubule interaction\, I will talk about the self-assembly of r
 ibosome motor during initiation of translation. Our theoretical model for 
 the assembly of ribosome captures all the major pathways and the key steps
  indicated by experiments. We obtain the distribution of first passage tim
 e and hence\, mean first passage time for the assembly of a ribosome motor
  considering all the possible error during the assembly.
LOCATION:Meeting room 3rd floor / Bertalanffy Bldg. \, ISTA
ORGANIZER:lalesch@ist.ac.at
SUMMARY:Ghanti Dipanwita: Stochastic Kinetics of Transient Joints in Multi-
 component Molecular Machines: Fluctuating Force\, Collective Behaviour and
  Emergent Chemo-Mechanics
URL:https://talks-calendar.ista.ac.at/events/1618
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