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DTSTART:20190331T030000
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DTSTART:20181028T020000
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DTSTAMP:20260404T015750Z
UID:5bd8145c11abc400937293@ist.ac.at
DTSTART:20181128T110000
DTEND:20181128T120000
DESCRIPTION:Speaker: Cory Dunn\nhosted by Fyodor Kondrashov\nAbstract: Prot
 eins localized to mitochondria by a carboxyl-terminal tail anchor (TA) pla
 y important roles in apoptosis and mitochondrial dynamics. We have carried
  out a deep mutational scanning approach to investigate sequential and str
 uctural features required for TA targeting to mitochondria. We found that 
 positively charged amino acids were much more acceptable at several positi
 ons within the membrane-associated portion of a mitochondria-directed TA t
 han negatively charged residues. These results provide strong\, in vivo ev
 idence that lysine and arginine can snorkel\, or partition the non-polar p
 ortion of their side chains into the hydrophobic region of the lipid bilay
 er while placing the terminal charge near the polar interface of the membr
 ane.TAs are not only used by cells to target proteins to mitochondria\, bu
 t also to direct proteins to other organelles. Moreover\, prokaryotes can 
 provide new genetic information to eukaryotes by horizontal gene transfer 
 (HGT)\, and such transfers are likely to have been particularly consequent
 ial during the early evolution of eukaryotes. I will outline our recent re
 sults regarding the targeting of bacterial TAs to different organelles in 
 yeast and human cells. Our results highlight the ease with which bacteria-
 derived sequences might target to distinct compartments of eukaryotic cell
 s following HGT\, and I discuss the importance of flexible recognition of 
 organelle targeting information during and after eukaryogenesis.Finally\, 
 I will provide a novel theory regarding the initial role of the proto-mito
 chondrial symbiont in the evolving eukaryote. It is unlikely that that the
  endosymbiont that eventually became the mitochondrion provided ATP to its
  host immediately upon entry to the archaeon\, raising the question of wha
 t benefits the endosymbiont initially did provide. Based on recent studies
  suggesting that mitochondria can maintain their temperature at a value mu
 ch higher than their surroundings\, I suggest that heat generated by the p
 roto-mitochondrial endosymbiont allowed its archaeal host to sample cooler
  environments.
LOCATION:Mondi Seminar Room 2\, Central Building\, ISTA
ORGANIZER:amally@ist.ac.at
SUMMARY:Cory Dunn: Organelle Assembly and Evolution
URL:https://talks-calendar.ista.ac.at/events/1585
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