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DTSTART:20190331T030000
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DTSTART:20181028T020000
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DTSTAMP:20260404T020021Z
UID:5bd03594d55a7006107419@ist.ac.at
DTSTART:20181205T110000
DTEND:20181205T120000
DESCRIPTION:Speaker: Sascha Martens\nhosted by Martin Loose\nAbstract: Auto
 phagy is an intracellular lysosomal bulk degradation pathway that ensures 
 cellular homeostasis by the removal of damaged and dangerous material from
  the cytoplasm. This is achieved by the sequestration of the cytoplasmic c
 argo material within double membraned organelles called autophagosomes. Th
 e selective sequestration of only specific cargo material is mediated by c
 argo receptors that link the cargo to the nascent autophagosomal membrane.
  How cargo selection\, membrane nucleation and growth are coupled is uncle
 ar. I will present our recent work on the yeast Atg19 and human p62 cargo 
 receptors derived from in vitro reconstitution systems and cell biology. I
 n particular\, I will discuss how they act sequentially during cargo conde
 nsation\, membrane nucleation and elongation to mediate the specific seque
 stration and subsequent degradation of cellular material.
LOCATION:Mondi Seminar Room 2\, Central Building\, ISTA
ORGANIZER:rsix@ist.ac.at
SUMMARY:Sascha Martens: Mechanisms of Selective Autophagy - From Phase Sepa
 ration to Cargo Degradation
URL:https://talks-calendar.ista.ac.at/events/1575
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