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DTSTART:20180325T030000
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DTSTART:20181028T020000
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DTSTAMP:20260424T143517Z
UID:5bcec12bb4378156113505@ist.ac.at
DTSTART:20181024T133000
DTEND:20181024T143000
DESCRIPTION:Speaker: Ulrich Elling\nhosted by Simon Hippenmeyer\nAbstract: 
 The basis for complexity of multicellular organisms is the diversity of ce
 ll types they are made of. Cell identities are set up by differentiation\,
  yet must be faithfully maintained thereafter and a failure to do so can r
 esult in pathologic states such as cancer. Moreover\, cell identities can 
 be experimentally overwritten by nuclear transfer or the expression of tra
 nscription factors such as most famously the Yamanaka cocktail. Much progr
 ess was made in our understanding of how lineage defining transcription fa
 ctors act\, however additional players and mechanisms during lineage ident
 ity conversion remain largely elusive.I will discuss new tools for genome 
 wide CRISPR screens\, that we developed in the lab with the aim of refinin
 g sensitivity and reproducibility of this method. Using these tools we hav
 e begun to systematically probe the genetics of cell identity conversions 
 and I will share recent progress on defining the path of induced neurogene
 sis by Ascl1 and Ngn2 expression.
LOCATION:Mondi Seminar Room 2\, Central Building\, ISTA
ORGANIZER:lmarr@ist.ac.at
SUMMARY:Ulrich Elling: New CRISPR tools to probe the genetics of cell ident
 ity change
URL:https://talks-calendar.ista.ac.at/events/1571
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