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DTSTART:20181028T020000
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DTSTAMP:20260404T020023Z
UID:5bc702df45336545440725@ist.ac.at
DTSTART:20181025T140000
DTEND:20181025T150000
DESCRIPTION:Speaker: Antal Rot\nhosted by Michael Sixt\nAbstract: Chemokine
 s and their receptors form signalling networks that control many physiolog
 ical and pathological processes. Chemokines trigger G-protein coupled rece
 ptors (GPCRs) to induce intracellular signalling cascades resulting in div
 erse cellular responses\, most notably\, directed cell migration. Chemokin
 es also bind to atypical chemokine receptors (ACKRs) that are structurally
  homologous to GPCRs\, but do not couple to G-proteins and fail to trigger
  the full spectrum of downstream signalling. Nevertheless\, ACKRs play uni
 que roles as they modify the distribution of chemokines in tissue microenv
 ironments and thus affect their functions. ACKR4 is a paradigmatic atypica
 l receptor binding three key homeostatic lymphoid chemokines\, CCL19\, CCL
 21 and CCL25\, which are scavenged following their ACKR4 binding. Accordin
 gly\, ACKR4 is expressed in the primary and secondary lymphoid organs wher
 e it was shown to pattern chemokine distribution. We found recently that\,
  in addition to the lymphoid organs\, ACKR4 is expressed in a multitude of
  organs and tissues by diverse discrete subsets of cell populations. Such 
 different and surprising tissue patterns of ACKR4 expression suggest new i
 n part organ-specific functions of this receptor.
LOCATION:Mondi Seminar Room 2\, Central Building\, ISTA
ORGANIZER:astawick@ist.ac.at
SUMMARY:Antal Rot: ACKR4!? What a nice receptor like you is doing in places
  like these?
URL:https://talks-calendar.ista.ac.at/events/1567
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