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DTSTART:20180325T030000
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DTSTAMP:20260404T053032Z
UID:5b5b0a2256d68485079711@ist.ac.at
DTSTART:20180808T130000
DTEND:20180808T140000
DESCRIPTION:Speaker: Fabrizio Lombardi\nhosted by Gasper Tkacik\nAbstract: 
 Bursting dynamics is a recurrent feature in natural phenomena\, and a fund
 amental property ofphysiological systems across the human body. In the bra
 in\, the near synchronous firing of manyneurons gives rise to collective b
 ehaviors such as oscillations and neuronal avalanches\, key featuresof the
  resting activity of cortical networks. In the first part of this talk\, I
  will discuss recent workson avalanche dynamics in cortex slice cultures a
 nd in mammalian brains (humans and rats) acrossthe sleep-wake cycle\, with
  a particular emphasis on the relationship between criticality and thetemp
 oral organization of neuronal avalanches. I will then switch the focus fro
 m the isolated brain tothe integrated network of organs in the human body\
 , where different complex physiological systemscontinuously interact to op
 timize and coordinate their function\, and produce distinct physiologicsta
 tes. Organ-to-organ interactions occur at multiple levels and spatiotempor
 al scales and areessential for an optimal global behaviour of the network.
  Despite the importance of theseinteractions for maintaining health\, litt
 le is known about their nature and dynamics. Here I willdemonstrate how ph
 ysiologic network topology and systems connectivity can be associated toem
 erging behaviors representative of distinct states and functions. I will a
 lso show that universal\,age-independent laws govern physiological network
 s at different levels of integration in the humanbody (brain-brain\, brain
 -organ and organ-organ)\, and that transitions across physiological states
  areassociated with specific changes in the network organization. These in
 vestigations represent a firststep towards a holistic approach to human ph
 ysiology that aims to associate distinct conditions tonetworks of interact
 ions inferred from synchronous recordings of several organs across the hum
 anbody\, and predict their evolution in response to perturbations (e.g. or
 gan failure\, medicaltreatments).
LOCATION:Meeting room 1st floor / Central Bldg. (I01.1OG - Zentralgebäude)
 \, ISTA
ORGANIZER:gtkacik@ist.ac.at
SUMMARY:Fabrizio Lombardi: The bursting brain and the integrated nature of 
 physiologic states: From neuronal avalanches to network physiology and bey
 ond
URL:https://talks-calendar.ista.ac.at/events/1332
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