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DTSTART:20180325T030000
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DTSTART:20181028T020000
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DTSTAMP:20260406T074320Z
UID:5b33779bebf41278033150@ist.ac.at
DTSTART:20180703T160000
DTEND:20180703T171500
DESCRIPTION:Speaker: Dr. Mehmet Ucar\nhosted by Edouard Hannezo\nAbstract: 
 Many active cellular processes such as organelle transport\, spindle organ
 ization\, and beating of flagella and cilia are driven by molecular motors
  kinesin\, dynein and myosin. These motor proteins can act collectively to
  generate large forces\, as in the large-scale organization of the mitotic
  spindle by kinesin and dynein\, and the role of myosin during actomyosin 
 contraction. Forces generated by different types of motors can increase ad
 ditively or sub-additively with increasing motor number\, depending on the
  motor type. Both experimentally and theoretically\, however\, the underly
 ing mechanism of force generation and force sharing by ensembles of motors
  remains controversial. Here we address this issue by introducing a theore
 tical model for cargo transport by elastically coupled molecular motors. W
 e outline the collective force generation profiles of different types of m
 otors and show that the variation in these profiles is mainly determined b
 y the difference in the detachment rates of single motors. We find that mo
 tors with a high stall force value cooperate more poorly than weak motors 
 due to an increased probability of strain-induced unbinding events from th
 e filament. Forces generated by weak motors\, on the other hand\, can even
  increase super-additively with increasing motor number for motors with lo
 w force-dependent unbinding rates or for fast and weak motors. We compare 
 our theoretical results with experimental data on kinesin-1 and illustrate
  that its sub-additive force generation profile arises from strain-induced
  unbinding and not from unequal force sharing between the individual motor
 s.
LOCATION:Meeting room 1st floor / Central Bldg. (I01.1OG - Zentralgebäude)
 \, ISTA
ORGANIZER:channezo@ist.ac.at
SUMMARY:Dr. Mehmet Ucar: Force generation and force sharing by elastically 
 coupled molecular motors
URL:https://talks-calendar.ista.ac.at/events/1302
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