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DTSTART:20180325T030000
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DTSTAMP:20260404T110123Z
UID:5b2b78120e55f345561872@ist.ac.at
DTSTART:20180625T110000
DTEND:20180625T121500
DESCRIPTION:Speaker: Oleksandr Ostrenko\nhosted by Carl-Philipp Heisenberg\
 nAbstract: Transport processes are essential for proper function of secret
 oryorgans or glands\, including liver\, pancreas\, and salivary glands.Abe
 rrant transport is associated with diseases\, like primary sclerosingchola
 ngitis (PSC) in the liver\, that have been a matter of clinical andtransla
 tional studies for a long time. Bodily fluid secretion is aresult of an in
 tricate combination of active transport by the epithelialcells and passive
  transport along a chemical potential gradient. Theformer involves vesicul
 ar trafficking that relies on small intracellularcompartments\, called ves
 icles\, and trans-membrane transporter proteinsas their cargo\, and active
  pumping of osmolites by respectivetransporter protein. For the latter\, o
 smosis drives the water fluxdirected against the chemical potential gradie
 nt induced by osmoliteexcess in the duct and\, thereby\, sets the secreted
  fluid in motion.Previous studies offer some qualitative insight into the 
 secretoryprocess\, but a detailed quantification has not yet been possible
 . Due tothe highly intricate geometry of the respective organs and non-lin
 earityof the underlying biophysical theory\, currently\, neither experimen
 talnor theoretical studies have arrived at a detailed quantitativeundersta
 nding of the processes underlying secretion.During my PhD\, I developed a 
 biophysical model to describe transportprocesses in the mammalian secretor
 y organs and glands. First\, I deriveda model for osmosis-driven fluid out
 flow from a channel with porouswalls and then used analytic tools to study
  it. Then I used my model tostudy and predict bile secretion and transport
  in the murine liver basedon data from intravital microscopy revealing a (
 minor) contribution ofperistalsis to bile flow. Finally\, I applied my mod
 el to a long-standingissue in the field of hepatology concerning administr
 ation ofursodeoxycholic acid (UDCA) in patients with PSC.
LOCATION:Meeting room 2nd floor / Bertalanffy Bldg. (I04.2OG - LAB)\, ISTA
ORGANIZER:lalesch@ist.ac.at
SUMMARY:Oleksandr Ostrenko: Quantitative modeling of bile secretion and tra
 nsport in the liver
URL:https://talks-calendar.ista.ac.at/events/1292
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