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DTSTART:20180325T030000
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DTSTART:20181028T020000
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DTSTAMP:20260403T220406Z
UID:5b1e2c74d0530202005109@ist.ac.at
DTSTART:20180716T100000
DTEND:20180716T110000
DESCRIPTION:Speaker: Guy Reeves\nhosted by Nick Barton\nAbstract: Attempts 
 to replicate genetic studies of highly complex traits are often misguided\
 , compromised due to the almost inevitable differences in the sampling of 
 alleles and their frequencies between studies. The inferential consequence
 s of this frequently unavoidable biological and analytical reality can be 
 frustrating for some researchers. This can also have the effect of obscuri
 ng the relative strengths and weaknesses of the range of experimental and 
 analytical approaches applied in studies aimed at identifying QTLs or eluc
 idating the genetic architecture of highly complex traits. In an effort to
  explore multiple approaches within the same biological experiment we esta
 blished a 15 generation pedigree incorporating > 1700 single pair crosses 
 and >90\,000 phenotyped individuals. This was done using Drosophila melano
 gaster for the phenotypic trait: length of the pupal case (h2= 0.44 ?0.04 
 SE & H2= 0.58). The use of an automated phenotyping and data recording sys
 tem made it possible to record the complete ancestry of every individual w
 ithin the pedigree. The pedigree was initiated using 8 autosomes\, 2 Y-chr
 omosomes and 2 mito-types. Within part of the pedigree a select and re-seq
 uence approach with x28 independent replicates was performed.Within\, this
  common biological framework we can conduct the following analytical appro
 aches to assess their relative strengths and weaknesses in minimising the 
 degree of missing heritability: association\, random-forest\, reproduced a
 llele-frequency changes in response to selection\, extended family-analysi
 s and tests of epistasis. This analysis was based on >300 complete sequenc
 ed genomes. It is anticipated that this study and phenotype could represen
 t a rich resource with which to examine analytical approaches when it is p
 laced on-line.
LOCATION:Meeting room 1st floor / Central Bldg. (I01.1OG - Zentralgebäude)
 \, ISTA
ORGANIZER:abonvent@ist.ac.at
SUMMARY:Guy Reeves: A model experiment of parallel selection for elucidatin
 g the architecture of complex traits
URL:https://talks-calendar.ista.ac.at/events/1278
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