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DTSTART:20180325T030000
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DTSTART:20181028T020000
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DTSTAMP:20260406T074823Z
UID:5b1a1d4305c9f224260158@ist.ac.at
DTSTART:20180620T160000
DTEND:20180620T170000
DESCRIPTION:Speaker: Stephan J.Sigrist\nhosted by Johann Georg Danzl\nAbstr
 act: Recently\, high throughput electron microscopy has started to reveal 
 complete wiring diagrams of circuits and whole brain regions\, for example
  in the Drosophila olfactory sensory and learning center. However\, effica
 cy\, timing\, and frequency tuning of synaptic vesicle release are highly 
 diversified across the development of brain circuitry. Systematic knowledg
 e regarding the functional features of synapse types will be required for 
 a satisfactory understanding and functional modeling of neural circuits. U
 sing light superresolution microscopy\, we provide evidence that presynapt
 ic active zone scaffold protein diversity controls functional diversity ac
 ross Drosophila brain synapses: distinct patterns of scaffold complexes di
 fferentially recruit specific Unc13 isoforms to steer transmission dynamic
 s in a neuron-specific manner by conferring diverse nanometer-precise posi
 tioning of vesicle release sites to Ca2+ channels. In this manner\, a comp
 ositional code of such stereotypic release modules diversifies synapse res
 ponse properties. Our analysis provides nanoscopic molecular fingerprints 
 of synapse types which helps in understanding specific synaptic features i
 n circuit modeling.Key publications: 1.Fulterer A\, Andlauer TFM\, Ender A
 \, et al. Active Zone Scaffold Protein Ratios Tune Functional Diversity ac
 ross Brain Synapses. Cell reports 2018\;23:1259-74.2.Bohme MA\, Beis C\, R
 eddy-Alla S\, et al. Active zone scaffolds differentially accumulate Unc13
  isoforms to tune Ca(2+) channel-vesicle coupling. Nature neuroscience 201
 6\;19:1311-20.
LOCATION:Mondi Seminar Room 2\, Central Building\, ISTA
ORGANIZER:rsix@ist.ac.at
SUMMARY:Stephan J.Sigrist: Active zone scaffold proteins tune functional di
 versity across brain synapses
URL:https://talks-calendar.ista.ac.at/events/1276
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