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DTSTART:20180325T030000
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DTSTART:20181028T020000
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DTSTAMP:20260405T192011Z
UID:5b07d6c6acf10963060648@ist.ac.at
DTSTART:20180604T110000
DTEND:20180604T120000
DESCRIPTION:Speaker: Scott D. Boyd\, M.D.\, Ph.D.\nhosted by Johann Georg D
 anzl\nAbstract: Almost all successful vaccines and many protective immune 
 responses to infections rely on antibody production and the formation of B
  cell memory\, but the diversity of individual humoral responses and the r
 elative inaccessibility of the bone marrow and secondary lymphoid tissues 
 have posed challenges in human immunological research. By combining single
 -cell analysis of antibody specificities and high-throughput sequencing of
  B cell receptor repertoires\, we have identified common features of the a
 ntibody responses of human subjects to vaccinations and infections\, inclu
 ding convergent antibody species with highly similar sequences. By analyzi
 ng the clonal relationships between bone marrow plasma cell populations an
 d peripheral blood plasmablasts and memory B cells during vaccine response
 s we can assess which clones are stimulated by vaccination\, and which con
 tribute to the long lasting bone marrow plasma cell pool. We are currently
  applying these approaches to several kinds of primary and secondary human
  immune responses\, to identify vaccine-specific or infectious agent-speci
 fic characteristics of B cell memory formation and effective humoral immun
 ity. Most recently\, we have used similar methodologies to analyze allerge
 n-specific IgE repertoires in peanut allergic patients\, and track the evo
 lution of B cell clones during desensitizing oral immunotherapy.
LOCATION:Seminar Room\, Lab Building East\, ISTA
ORGANIZER:rsix@ist.ac.at
SUMMARY:Scott D. Boyd\, M.D.\, Ph.D.: B cell repertoire responses in vaccin
 ation\, infection and allergy
URL:https://talks-calendar.ista.ac.at/events/1260
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