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TZID:Europe/Vienna
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DTSTART:20180325T030000
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DTSTART:20181028T020000
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BEGIN:VEVENT
DTSTAMP:20260406T042324Z
UID:5af1827da4312629105962@ist.ac.at
DTSTART:20180606T123000
DTEND:20180606T133000
DESCRIPTION:Speaker: Melanie Salvermoser\nhosted by Jörg Renkawitz\nAbstra
 ct: Neutrophil extravasation and interstitial migration are important step
 s during the recruitment of neutrophils to sites of inflammation. In the p
 resent study\, we addressed the functional importance of the unconventiona
 l class I myosin 1f (Myo1f) for neutrophil trafficking during acute inflam
 mation. In contrast to leukocyte rolling and adhesion\, the genetic absenc
 e of Myo1f severely compromised neutrophil extravasation into the inflamed
  mouse cremaster tissue when compared to Myo1f+/+ mice as studied by intra
 vital microscopy. Similar results were obtained in experimental models of 
 acute peritonitis and acute lung injury. In contrast to 2D migration which
  occurred independently of Myo1f\, Myo1f was indispensable for neutrophil 
 migration in 3D environments\, i.e. transmigration and migration in collag
 en networks as it regulated squeezing and dynamic deformation of the neutr
 ophil nucleus during migration through physical barriers. Thus\, we provid
 e evidence for an important role of Myo1f in neutrophil trafficking during
  inflammation by specifically regulating neutrophil extravasation and migr
 ation in 3D environments.
LOCATION:Mondi Seminar Room 1\, Central Building\, ISTA
ORGANIZER:astawick@ist.ac.at
SUMMARY:Melanie Salvermoser: Myosin 1f is specifically required for neutrop
 hil migration in 3D environments during acute inflammation
URL:https://talks-calendar.ista.ac.at/events/1241
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