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DTSTART:20180325T030000
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DTSTAMP:20260404T094134Z
UID:5a3a343af0cc3021653971@ist.ac.at
DTSTART:20180518T150000
DTEND:20180518T160000
DESCRIPTION:Speaker: Namiko Mitarai\nhosted by Gasper Tkacik\nAbstract: The
  phage pressure is believed to be an important factor to shape microbial c
 ommunity and a driving force of their evolution\, and yet we are far from 
 having a full picture of their warfare. In this talk\, we discuss various 
 facets of the phage-bacteria interactions. First\, we analyze the competit
 ive exclusion of phage-bacteria ecosystem using Lotka-Volterra equations [
 1]. The analysis is consistent with the observed strong correlation betwee
 n the phage type richness and the bacteria type richness\, and shows the n
 arrowing parameter space of coexistence for larger richness. The coevoluti
 onary arms race typically favor high growth rate but a phage that infects 
 two bacterial strains differently can occasionally eliminate the fastest g
 rowing bacteria\, resulting in abrupt resetting of the Red-Queens race and
  constrains the local diversity.  We then extend our focus to spatially st
 ructured habitat [2\,3]. Numerical simulation of phage attack on a microco
 lony predicts that bacteria growing as a dense colony provides a spatial r
 efuge by exposing only the bacterial cells on the surface of the colony to
  a phage attack [3]. When the colony size is below a critical size at the 
 time of exposure to phages\, bacteria will be eliminated\, while when the 
 colony size is above the critical size\, the colony can survive and grow d
 espite the persistent phage attack on the surface. We show that experiment
 al result using the virulent version of phage P1 and the host Escherichia 
 Coli is consistent with this prediction. We study the parameter dependence
  of the critical size by numerical simulation\, and predict that the phage
  with lower adsorption rate will actually kill a colony better. Our findin
 gs indicate that the spatial structure of the bacterial population plays a
 n important role in phage-bacteria coexistence.
LOCATION:Mondi Seminar Room 3\, Central Building\, ISTA
ORGANIZER:rgrah@ist.ac.at
SUMMARY:Namiko Mitarai: Phage vs. Bacteria: The art of war among the unseen
  majority
URL:https://talks-calendar.ista.ac.at/events/1231
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