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TZID:Europe/Vienna
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DTSTART:20180325T030000
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DTSTART:20181028T020000
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BEGIN:VEVENT
DTSTAMP:20260403T220520Z
UID:5acc9bd63687c419285102@ist.ac.at
DTSTART:20180425T130000
DTEND:20180425T140000
DESCRIPTION:Speaker: Oliver Bell\nhosted by Simon Hippenmeyer\nAbstract: Tr
 anscriptional silencing by Polycomb group (PcG) proteins is a major paradi
 gm for epigenetic inheritance from fly to human. The Polycomb Repressive C
 omplexes PRC1 and PRC2 catalyse distinct chromatin modifications to enforc
 e gene silencing. However\, the mechanisms underlying the inheritence of t
 ranscriptional silencing by different PRC complexes are not known. Address
 ing this question has been extremely challenging due to technical limitati
 ons that do not discern the initiation from sequence-independent maintenan
 ce of repression. We have solved this problem by developing an approach to
  reversibly recruit PRC1 or PRC2 to transcriptionally inactive or active c
 hromatin in mouse embryonic stem cells. For the first time\, we directly a
 nd systematically interrogate the ability of different PcG complexes to (1
 ) form repressive chromatin structure\, (2) initiate gene silencing\, and 
 (3) maintain silencing. I will present an unexpected division of labour be
 tween different PRC1 and PRC2 complexes in epigenetic silencing.
LOCATION:Seminar Room\, Lab Building East\, ISTA
ORGANIZER:wkoelbl@ist.ac.at
SUMMARY:Oliver Bell: How cell fate decisions are maintained by Polycomb Rep
 ressive Complexes
URL:https://talks-calendar.ista.ac.at/events/1211
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