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DTSTART:20180325T030000
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DTSTAMP:20260404T203403Z
UID:5ab8cb2227638549227747@ist.ac.at
DTSTART:20180404T100000
DTEND:20180404T110000
DESCRIPTION:Speaker: Rebecca Petri\nhosted by Novarino\nAbstract: microRNAs
  (miRNAs) are 20-24 nucleotides small\, single-stranded\, non-coding RNAs.
  They associate with Argonaute (AGO) proteins and exert their function by 
 inhibition or degradation of messenger RNAs. A single miRNA can target hun
 dreds of genes and one gene can be targeted by several miRNAs\, hereby giv
 ing rise to a complex post-transcriptional network. In the brain\, hundred
 s of miRNAs are expressed and several are implicated in the regulation of 
 important neuronal functions and brain disorders. However\, many questions
  remain concerning the regulatory role of miRNAs in the brain. In the firs
 t part of my talk I will show an important role for miRNAs in adult neurog
 enesis. We recently showed that miR-125 controls functional integration of
  adult-born interneurons into the olfactory bulb (OB) and that let-7 is th
 e most abundant miRNA in newborn OB interneurons. Moreover\, we demonstrat
 ed that let-7 controls radial migration of newborn neurons through positiv
 e regulation of neuronal autophagy\, thereby revealing a novel link betwee
 n miRNAs and autophagy in adult neurogenesis which has important implicati
 ons for neurodegenerative diseases such as Huntingtons disease.  In the se
 cond part of my talk\, I will show that transposable elements (TE) are an 
 important source for miRNAs and their target sites\, hereby giving rise to
  a TE-dependent miRNA-target network. Together\, these findings extend the
  current knowledge on the role of miRNAs in the brain\, and ultimately pro
 vide an insight into how disturbances in miRNA regulation can have severe 
 consequences on neuronal functions.
LOCATION:Seminar Room\, Lab Building East\, ISTA
ORGANIZER:wkoelbl@ist.ac.at
SUMMARY:Rebecca Petri: The Regulatory Role of miRNAs in the Mouse and Human
  Brain
URL:https://talks-calendar.ista.ac.at/events/1191
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